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Further evidence indicates that microbial dysbiosis exacerbates renal inflammation and accelerates the progression of HN by impairing intestinal barrier integrity and increasing permeability, thereby facilitating the translocation of harmful metabolites, such as pro-inflammatory cytokines and uremic toxins, into the systemic circulation ( Figure 2 ) [152, 153]

[PubMed] [Google Scholar] [8].Lage SL, Amaral EP, Hilligan KL, Laidlaw E, Rupert A, Namasivayan S, et al

When the combinations are chosen correctly and run on a supervised schedule, the results from each compound reinforce rather than compete with one another

Tabung FK, Smith-Warner SA, Chavarro JE, et al

Vasiliou et al., 1995)